VIROLOGY: Retooling Degradation Factories

Retooling chemical probes

In 2007, scientists from Sirtris Pharmaceuticals along with academic collaborators reported the identification of a series of compounds that activated SIRT1 in vitro and led to beneficial effects in mouse models of type II diabetes (Nature 450, 712–716, 2007). It is widely believed that based at least in part on the discovery of SIRT1 activator compounds, GSK acquired Sirtris for $720 million i...

Reticulophagy and Ribophagy: Regulated Degradation of Protein Production Factories

During autophagy, cytosol, protein aggregates, and organelles are sequestered into double-membrane vesicles called autophagosomes and delivered to the lysosome/vacuole for breakdown and recycling of their basic components. In all eukaryotes this pathway is important for adaptation to stress conditions such as nutrient deprivation, as well as to regulate intracellular homeostasis by adjusting or...

Virology

This volume of the Handbook of Behavioral Neurobiology contains a wealth of information on the neural control of movement. Overall, the approach of the authors is to stress basic experimental data. Therefore, the book will be an excellent reference source for basic scientists as well as clinicians. The first chapters of the book examine the role of muscle in movement. These chapters discuss rec...

Virology.

Retooling institutional support infrastructure for clinical research.

Clinical research activities at academic medical centers are challenging to oversee. Without effective research administration, a continually evolving set of regulatory and institutional requirements can divert investigator and study team attention away from a focus on scientific gain, study conduct, and patient safety. However, even when the need for research administration is recognized, ther...